Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally.Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline.In recent years, the presence of non-canonical G-quadruplex (GQ) secondary s
Background: The authors have g fuel spiderverse previously published the complete mitochondrial genome (mitogenome) sequences of two indigenous Mesoamerican populations, Mazahua (n = 25) and Zapotec (n = 88).Methods: This study determined the complete mitogenome sequences of nine unrelated individuals from the indigenous Maya population living in M
Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively fr9345 inaccessible.Here, we identify sphingomyelin phosphodiesterase 1 (SMPD1), an enzyme that regulates the conversion of sphingomyelin to ceramide, as an
Background The purpose of this study was to study the role of thymidylate synthetase (TYMS) and B-cell lymphoma-2 like 1 (BCL2L1) in the occurrence and development of colorectal cancer and its potential regulatory mechanism.Methods The Cancer Genome heat experience sitteunderlag Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed to examin